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Subject: =?Windows-1252?Q?Tolera_Therapeutics_gets_$4M_for_organ_transplant_reject?=
	=?Windows-1252?Q?ion_drug_=AB_MedCity_News?=
Date: Thu, 24 Jun 2010 13:15:24 -0400
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<DIV class=3Dbyline>6.7.10 | <SPAN class=3Dauthor><A=20
href=3D"http://www.medcitynews.com/author/bglenn/">Brandon =
Glenn</A></SPAN> |=20
Kalamazoo, Michigan</DIV>
<H2>Tolera Therapeutics gets $4M for organ transplant rejection =
drug</H2>
<DIV class=3Dstory-main-text>
<P><A=20
href=3D"http://www.medcitynews.com/2010/06/tolera-therapeutics-gets-4m-fo=
r-organ-transplant-rejection-drug/tolera-therapeutics/"=20
rel=3D"attachment wp-att-30228"><IMG class=3D"alignright size-full =
wp-image-30228"=20
title=3D"tolera therapeutics" alt=3D""=20
src=3D"http://www.medcitynews.com/wordpress/wp-content/uploads/tolera-the=
rapeutics.jpg"=20
width=3D170 height=3D108></A>Cleveland Clinic spinoff <A=20
href=3D"http://www.tolera.com/index.html">Tolera Therapeutics Inc.</A> =
has raised=20
more than $4 million in equity to continue developing a drug that fights =
organ=20
rejection in transplant patients, according to a <A=20
href=3D"http://www.sec.gov/Archives/edgar/data/1451072/000145107210000003=
/xslFormDX01/primary_doc.xml">regulatory=20
filing</A> with the Securities and Exchange Commission.</P>
<P>The Series B funding will go toward a Phase 2 clinical trial of =
Tolera=E2=80=99s lead=20
drug candidate, TOL101, said <A=20
href=3D"http://www.tolera.com/execution_team.html">James Herrmann</A>, =
the=20
company=E2=80=99s chief operating officer and co-founder.</P>
<P>The drug is designed to <A=20
href=3D"http://blog.mlive.com/followthemoney/2009/11/kalamazoo_firm_wants=
_to_start.html">suppress=20
the immune systems</A> of patients who have received organ transplants, =
which=20
can fail because the body rejects and attacks the transplanted organ. =
Tolera has=20
begun the trial and expects to complete it in a year, Herrmann said.</P>
<P></P>
<DIV class=3Dmedcity-paid-inline><A=20
href=3D"http://www.lifesciencealleyconference.org/new_technology_showcase=
.html"><IMG=20
alt=3D""=20
src=3D"http://www.medcitynews.com/features/ui-2.0/ads/life-science-alley.=
jpg"></A>
<DIV class=3Dmedcity-paid-inline-label>Advertisement</DIV></DIV>Tolera =
also plans=20
to clinically investigate the drug=E2=80=99s ability to fight other <A=20
href=3D"http://www.mult-sclerosis.org/autoimmunity.html">autoimmune =
disorders</A>,=20
such as Type 1 diabetes and multiple sclerosis, Herrmann said. Those =
trials=20
could start in about a year.
<P></P>
<P>The company may raise another $2 million for the round, bringing the =
total to=20
$6 million, if it can find new investors. So far, the latest round =
includes=20
contributions from Tolera=E2=80=99s existing investors, Herrmann =
said.</P>
<P>In 2008, Tolera raised <A=20
href=3D"http://blog.cleveland.com/medical/2008/06/tolera_therapeutics_get=
s_8_mil.html">an=20
$8 million Series A round</A>. <A =
href=3D"http://www.tmvp.com/">Triathlon Medical=20
Ventures</A> in Cincinnati led the round, which included contributions =
from the=20
<A =
href=3D"http://www.southwestmichiganfirst.com/venturefund.cfm">Southwest =

Michigan First Life Science Fund</A> in Kalamazoo and <A=20
href=3D"http://www.hopentherapeutics.com/">Hopen Therapeutics</A> Inc. =
in Grand=20
Rapids, Mich.</P>
<P>The company has raised $14 million since its inception, Herrmann =
said.</P>
<P>Tolera was chosen as one of this year=E2=80=99s (pdf) =E2=80=9C<A=20
href=3D"http://www.tolera.com/news/PRMI50_060410.pdf">Michigan 50 =
Companies to=20
Watch</A>=E2=80=9D in April by local economic development groups.</P>
<P>Cleveland Clinic Innovations spun off Tolera in 2007. The company =
moved to=20
Kalamazoo in mid-2008 to take advantage of the area=E2=80=99s drug =
development resources=20
and to be closer to investors, Herrmann said.</P></DIV>
<DIV class=3Dclearer></DIV>
<DIV class=3Dmeta>
<DIV class=3Dmeta-thumbnail><IMG class=3Dphoto alt=3D"Brandon Glenn"=20
src=3D"http://www.medcitynews.com/wordpress/wp-content/uploads/userphoto/=
bglenn.thumbnail.jpg"=20
width=3D56 height=3D70></DIV>
<DIV class=3Dmeta-author>
<H2>Brandon Glenn</H2>
<P>Brandon Glenn is a staff reporter for MedCity News.</P></DIV>
<DIV class=3Dmeta-tags>Tags: <A =
href=3D"http://www.medcitynews.com/tag/business/"=20
rel=3Dtag>Business</A>, <A =
href=3D"http://www.medcitynews.com/tag/cleveland-clinic/"=20
rel=3Dtag>Cleveland Clinic</A>, <A=20
href=3D"http://www.medcitynews.com/tag/hospitals/" =
rel=3Dtag>hospitals</A>, <A=20
href=3D"http://www.medcitynews.com/tag/kalamazoo/" =
rel=3Dtag>Kalamazoo</A>, <A=20
href=3D"http://www.medcitynews.com/tag/michigan/" =
rel=3Dtag>Michigan</A>, <A=20
href=3D"http://www.medcitynews.com/tag/tolera-therapeutics/" =
rel=3Dtag>Tolera=20
Therapeutics</A>, <A=20
href=3D"http://www.medcitynews.com/tag/triathlon-medical-ventures/"=20
rel=3Dtag>Triathlon Medical Ventures</A></DIV>
<DIV class=3Dclearer></DIV></DIV>
<DIV class=3Dcomments>
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Content-Location: http://www.medcitynews.com/wordpress/index.php?wordtube-js=true&ver=2.0


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}
------=_NextPart_000_0000_01CB139F.4E099610
Content-Type: application/octet-stream
Content-Transfer-Encoding: quoted-printable
Content-Location: http://www.medcitynews.com/ui-2.0/scripts/jquery/jquery-1.3.2.min.js

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 * jQuery JavaScript Library v1.3.2=0A=
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